AFFIRM
ENZA+ADT vs PLB+ADT
L2
Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
First author: Howard I. Scher
ARAMIS
DARO+ADT vs PLB+ADT
ADJ
Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer
First author: Karim Fizazi
ARASENS
DARO+ADT+doce vs PLB+ADT+doce
L1
Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer
First author: Matthew R. Smith
ARCHES
ENZA+ADT vs PLB+ADT
L1
A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer
First author: Andrew J. Armstrong
CARD
CABA+pred+ADT vs ABI+pred/ENZA+ADT
L2
Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer
COU-AA-301
ABI+pred+ADT vs PLB+pred+ADT
L2
Abiraterone and Increased Survival in Metastatic Prostate Cancer
First author: Johann S. de Bono
COU-AA-302
ABI+pred+ADT vs PLB+pred+ADT
L1
Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
First author: Charles J. Ryan
ENZAMET
ENZA+ADT vs NSAA+ADT
L1
Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer
LATITUDE
ABI+pred+ADT vs PLB+PLB+ADT
L1
Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer
First author: Karim Fizazi
PREVAIL
ENZA+ADT vs PLB+ADT
L1
Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
PROSPER
ENZA+ADT vs PLB+ADT
ADJ
Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer
First author: Maha Hussain
PROfound
OLAP vs ENZA / ABIR
L3
Olaparib for Metastatic Castration-Resistant Prostate Cancer
SPARTAN
APA+ADT vs PLB+ADT
ADJ
Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
First author: Matthew R. Smith
STAMPEDE
ABI+pred+ADT vs ADT
L1
Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
TITAN
APA+ADT vs PLB+ADT
L1
Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer
TROPIC
CABA+pred+ADT vs mitox+pred+ADT
L2
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment
First author: J.S. de Bono
VISION
Lu-PSMA-617 vs SoC
L3
Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer