APHINITY
PERT+TRAS+chemo vs PLB+TRAS+chemo
ADJ
Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer
First author: Gunter von Minckwitz
Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer
CLEOPATRA
PERT+TRAS+doce vs PLB+TRAS+doce
L1
Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer
First author: Sandra M. Swain
DESTINY-Breast03
TRASDRX vs TDM1
L2
Trastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer
Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation
First author: Jennifer K. Litton
EMILIA
TDM1 vs lapa+cape
L2
Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
First author: Sunil Verma
HER2CLIMB
TUCA+TRAS+cape vs PLB+TRAS+cape
L3
Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer
First author: R.K. Murthy
IMpassion130
ATEZ+nabpac vs PLB+nabpac
L1
Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
KATHERINE
TDM1 vs tras
ADJ
Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer
First author: G. von Minckwitz
KEYNOTE 522
PEMB+chemo vs PLB+chemo
NADJ
Pembrolizumab for Early Triple-Negative Breast Cancer
MONALEESA-2
RIBO+letr vs PLB+letr
L1
Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer
First author: Gabriel N. Hortobagyi
MONALEESA-3
RIBO+fulv vs PLB+fulv
L1
Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer
First author: Dennis J. Slamon
MONALEESA-7
RIBO+ET vs PLB+ET
L1
Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer
First author: A.N.J. Tutt
Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation
First author: Mark Robson
PALOMA-3
PALB+fulv vs PLB+fulv
L1
Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer
First author: N.C. Turner
SOLAR-1
ALPE+fulv vs PLB+fulv
L1
Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer
monarchE
ABEM|ET vs ET
ADJ
Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer
First author: Stephen R. D. Johnston